氯米帕明合并劳拉西泮治疗伴躯体症状抑郁症安全高效


  伴躯体症状的抑郁症是指在抑郁发作中有明显的躯体症状与自主神经系统症状,而无相应的躯体疾病,用氯米帕明合并劳拉西泮治疗伴躯体症状的抑郁症患者,对其临床疗效及不良反应进行观察,现报告如下:

  目的:观察氯米帕明治疗伴躯体症状抑郁症疗效。

  方法:29例伴躯体症状抑郁症患者用氯米帕明合并劳拉西泮治疗6周。应用汉密尔顿抑郁量表(HAMD,17项)及副反应量表(TESS)于治疗前及治疗第2、4、6周末各评定1次。

  结果:氯米帕明治疗2周、4周、6周后HAMD总分与治疗前相比差异均非常显著,不良反应少。

  结论:氯米帕明对治疗伴躯体症状的抑郁症疗效好,安全性高,患者依从性好,适宜于临床使用。

  本研究结果显示,氯米帕明合并劳拉西泮治疗伴躯体症状的抑郁症疗效较好。服用氯米帕明合并劳拉西泮起效快,1周后有改善,2周后明显好转,4~6周症状基本消失。随着治疗时间延长,抑郁症状逐渐消失。

  伴躯体症状的抑郁症患者,首先感觉到躯体不适为主诉,而未涉及情绪方面症状,多数就诊于综合医院治疗,因此,大多数患者未能得到及时有效的治疗。经多方检查和治疗,疗效欠佳,因对自己的疾病不能有正确的认识,认为自己患了不治之症,随之产生严重焦虑、抑郁的情绪,服用劳拉西泮能很快控制病人焦虑症状,改善病人睡眠。由于氯米帕明主要作用在阻断中枢神经系统去甲肾上腺素和5-羟色胺的再摄取,是强的5-羟色胺再摄取抑制剂,而其活性代谢物去甲氯丙咪嗪却是同等强的NE摄取抑制剂。发挥抗抑郁及抗焦虑作用,也许这就是其对多种躯体症状为主诉的抑郁症有较好疗效的原因,其作用机制还有待进一步研究。

  本文观察氯米帕明合并劳拉西泮治疗伴躯体症状抑郁症的有效率为89.7%,与文献报道一致。因三环类药对心脏的毒性作用较大,使用范围受限。但经过这几年用药的观察,氯米帕明对心脏毒性相应比其它三环类药较轻,用药时定期检测血、尿、肝功能、心电图等,不良反应有轻度口干、出汗等,无须作特殊处理,随着用药时间的延长,有些不良反应会逐渐消失,便秘患者多吃蔬菜和水果多能改善。针对抑郁症早期患者的食欲差,在服用药物的同时加用每日腹部按摩30分钟,增加了胃肠蠕动,起到很好的辅助效果。

  氯米帕明合并劳拉西泮([url=http://www.fuguantang.com/goods/994.html]http://www.fuguantang.com/goods/994.html[/url])治疗抑郁症躯体化的患者疗效明显,价格低廉,仍是目前大部分患者治疗的首先选择。


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